When you run Interference Detection, the interferences between the threads of fasteners are reported. Generally, you want to ignore these interferences. You can create a Fasteners folder to segregate interferences involving fasteners.
Not all interferences in the Fasteners folder are between threads. You must examine the interferences in the Fasteners folder to determine whether or not they create problems in your assembly. For example, an interference could exist between the heads of two adjacent bolts, which you need to eliminate by modifying the assembly.